Collagen Biostimulators

Collagen biostimulators are a type of injectable treatment that are injected into specific areas of the face or body to stimulate collagen production in the skin, improve volume, skin quality and address sagging or wrinkles.

Collagen biostimulators gradually replace lost collagen—the most common protein in the body that is used to form a framework to support cells and tissue—for results that can last up to two years. 

Collagen is a key structural component of smooth, healthy-looking skin. With aging, the body’s collagen production decreases. In fact, facial aging begins in your 20s, when you start losing about 1% of the collagen in your skin per year. This is when you may start to notice the formation of wrinkles.

Skin firmness decreases as a result of both internal factors (genetics and natural aging) and external factors (sun exposure, smoking, stress, etc.). The loss of collagen causes loose and saggy skin, shallow wrinkles, deep folds and loss of facial volume.

Collagen biostimulators works to improve facial wrinkles and skin thickness gradually, as it stimulates natural collagen production to restore the inner structure of the skin, thereby recreating a youthful appearance. 

An increase in collagen by 66% has been observed 3 months after treatment in a study where collagen biostimulators has been used for the treatment of nasolabial fold wrinkles with consistent improvement observed for up to 25 months.

Collagen biostimulators typically contain biocompatible substances that act as a catalyst to trigger collagen production in the injected areas. The most commonly used biostimulators include poly-L-lactic acid (PLLA) and calcium hydroxylapatite (CaHA).

Poly-L-lactic acid (PLLA): PLLA is a biocompatible and biodegradable synthetic substance that has been used in various medical applications for many years. When injected, PLLA stimulates collagen synthesis in the skin, gradually improving skin volume and reducing the appearance of wrinkles and sagging. The effects of PLLA can last for a couple of years, depending on the individual and treatment area. Multiple sessions are usually required for optimal results.

Calcium hydroxylapatite (CaHA): CaHA is a naturally occurring mineral-like compound that is commonly found in bone. In cosmetic use, CaHA is suspended in a gel-like solution and injected into the skin. It works by stimulating collagen production while also providing immediate volume to the treated areas. The effects can typically last up to a year or more. Multiple treatments may also be needed for optimal results.

Collagen biostimulators are commonly used for the treatment of nasolabial folds, marionette lines, and areas of sagging and facial volume loss. They can also be used on other parts of the body, such as the hands, to improve skin quality and volume.

It is important to note that collagen biostimulators should only be administered by trained medical professionals and like any medical procedure, they come with potential risks and side effects, such as swelling, redness and bruising at the injection site. 

If you are considering collagen biostimulators or any other cosmetic procedure, it is it is advisable to schedule a consultation with Dr Donald Ng who can assess your specific needs, discuss the potential benefits and risks, and determine if collagen biostimulators are appropriate for you.

Before and After Photos

In compliance with MOH guidelines in Singapore, we are not allowed to post before-and-after images on our website and social media platforms. However, we are more than willing to share such images for your perusal during your in-clinic consultation with us.